I’m sure that many of you have already heard my COVID booster story. (I got my first COVID infection fifteen days after my first and only COVID booster). This story is now worth revisiting because of a recent article published in the Journal of Infection titled, “Post-vaccination IgG4 and IgG2 class switch associates with increased risk of SARS-CoV-2 infections.”
After reading about this study in C&C, I went to the March 18, 2025 study itself. Basically what it said was that after the third COVID shot, there was a higher likelihood of getting COVID. This increased likelihood was due to an increase of Ig2 and Ig4 subclasses of antibodies after the third COVID shot. These types of antibodies are not nearly as efficient at preventing COVID, and it appears that the opposite occurs. Even more concerning was that this effect lasted for a long time. (After my one and only booster, I got COVID fifteen days later. However, in addition I got Covid twice more in the following years, whereas before my booster, I did not have COVID! … serendipity? … or perhaps the booster was a “gift that just kept on giving.”
3/31/25
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Political commentary from a conservative Californian